Eurycoma longifolia jack (Tongkat Ali) induces penile erection and delays ejaculation

9-hydroxycanthin-6-one, an active compound found in Eurycoma longifolia jack, contributed to the aphrodisiac effect by antagonizing the smooth muscle tone of corpus cavernosum as well as the seminal vesicle through interfering with Ca2+ mobilization.

Effect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men.

Logistic regression analysis showed that Maca has an independent effect on sexual desire at 8 and 12 weeks of treatment, and this effect is not because of changes in either Hamilton scores for depression or anxiety or serum testosterone and oestradiol levels. In conclusion, treatment with Maca improved sexual desire.

Vasodilation for the permanent increase in length and girth of a male subject’s penis
Patent US 20050065159 A1

A method for causing a permanent increase in the length and girth of a male subject's penis, the method comprising treatment comprising the step of (a) administering to the male an effective amount of a vasodilator selected from the group consisting of a vasodilator per se and compositions thereof comprising a pharmaceutically-acceptable diluent or carrier, to induce a cumulative prolonged engorgement of the subject's penis; and (b) repeating step (a) as necessary to cause the increase during the treatment. A potentiator which enhances the effect of the vasodilator may also be used.

Patent summary:
1. Consistent vasodilation through administration of vasodilators (L-Arginine) can cause an increase during the treatment.
2. “Potentiators” that increase libido enhances the effect of the vasodilation process will increase the effectiveness of using vasodilators in increasing the length and girth of the penis.

Arginine for relieving symptoms of erectile dysfunction
Patent US 6565851 B2

Use of proanthocyanidins as an active ingredient of a stimulator as a source of arginine and a source of nitric oxide in the treatment of erectile dysfunction. The active ingredient stimulates the endothelial NO-synthase enzyme, which acts as a catalyst for the synthesis of nitric oxide from its substrate L-arginine or its salts. The nitric oxide in turn activates theguanylyl cyclase, which leads to an increased development of cyclic guanosine monophosphate, which causes relaxation of smooth muscles.

Blood vessel diameter may increase. The stimulator may also have Sildenafil or enzymes that inhibit an enzyme phosphodiesterase type5 from reducing an amount of the cyclic guanosine monophosphate. The substrate may be amino acid L-arginine, arginine salts or a dipeptide of arginine and aspartic acid.

Patent summary:
1. L-Arginine as a source of nitric oxide in the treatment of erectile dysfunction.
2. The combination of L-Arginine and PDE-5 inhibitors (Epimedium, Tongkat Ali, Muira Puama) exponentially increases the effectiveness of L-Arginine to treat erectile dysfunction.